Category : SAMe

SAMe (S-adenosyl-methionine)

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SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:Methylation (contributing methyl groups to activate certain molecules)The synthesis of polyamines (for cell growth gene expression neuronal regeneration etc.)Trans-sulfuration (synthesis of cysteine glutathione and other sulfate chemicals)SAMe occurs naturally in the body. It is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones nucleic acids proteins and phospholipids catecholamines and other neurotransmitters such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine dopamine and serotonin and also plays a role in other intracellular metabolic pathways.SAMe facilitates glutathione usage and maintains acetylcholine levels which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.SAMe levels may become depleted from sickness and age. Supplementation with the cofactors folate trimethylglycine (TMG or betaine) vitamins B6 and B12 together with SAMe appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine which keeps cell membranes fluid and is used in the brain to make the neurotransmitter acetylcholine.

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