SAM-e is an amino acid derivative that is found in all living cells SAM-e is also activated methionine (as essential amino acid) since it is formed by the combination of ATP with methionine.. Joint Strength: SAM-e supports the production of healthy connective tissues through transulfuration . In this process critical components of connective tissue including glucosamine and the condroitin sulfates are from SAM-e metabolites.. Brain Metabolism:SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-dopa dopamine and related hormones epinephrine and phosphatidylcholine (a component of lecithin). Liver: SAM –e metabolism supports the synthesis of glutathione (GSH) and glutathione – dependent enzymes (glutathion peroxidase and glutathione – S- transference) which are substances important for liver function.. Longevity: Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process . Proper methylation positively influences longevity.Other products from HerbsPro